• Product nameAnti-Apoptosis inhibitor 5 antibody
    See all Apoptosis inhibitor 5 primary antibodies
  • Description
    Mouse monoclonal to Apoptosis inhibitor 5
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 400-504 of Human Apoptosis inhibitor 5



Our Abpromise guarantee covers the use of ab56392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAntiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
    • Tissue specificityExpressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
    • Sequence similaritiesBelongs to the API5 family.
    • DomainTwo regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
    • Cellular localizationCytoplasm and Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic.
    • Information by UniProt
    • Database links
    • Alternative names
      • AAC 11 antibody
      • AAC-11 antibody
      • AAC11 antibody
      • Antiapoptosis clone 11 protein antibody
      • API 5 antibody
      • API-5 antibody
      • api5 antibody
      • API5 like 1 antibody
      • API5_HUMAN antibody
      • API5L1 antibody
      • Apoptosis inhibitor 5 antibody
      • Cell migration inducing gene 8 protein antibody
      • Cell migration-inducing gene 8 protein antibody
      • Fibroblast growth factor 2 interacting factor 2 antibody
      • Fibroblast growth factor 2-interacting factor antibody
      • FIF antibody
      • MIG 8 antibody
      • MIG8 antibody
      • Migration inducing protein MIG8 antibody
      • Protein XAGL antibody
      see all

    Anti-Apoptosis inhibitor 5 antibody images

    • Apoptosis inhibitor 5 antibody (ab56392) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.

    • Predicted band size : 58 kDa

    References for Anti-Apoptosis inhibitor 5 antibody (ab56392)

    This product has been referenced in:
    • Garcia-Jove Navarro M  et al. Api5 contributes to E2F1 control of the G1/S cell cycle phase transition. PLoS One 8:e71443 (2013). WB . Read more (PubMed: 23940755) »
    • Schlundt A  et al. Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions. Mol Cell Proteomics 8:2474-86 (2009). Read more (PubMed: 19542561) »

    See all 2 Publications for this product

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