Anti-Apoptosis inhibitor 5 antibody (ab99308)

Overview

  • Product name
    Anti-Apoptosis inhibitor 5 antibody
    See all Apoptosis inhibitor 5 primary antibodies
  • Description
    Rabbit polyclonal to Apoptosis inhibitor 5
  • Tested applications
    Suitable for: IHC-P, IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Immunogen correspondsto a region within amino acids 150-200 of Human Apoptosis inhibitor 5 (XP_508375.2).

  • Positive control
    • Hela whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99308 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
    • Tissue specificity
      Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
    • Sequence similarities
      Belongs to the API5 family.
    • Domain
      Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
    • Cellular localization
      Cytoplasm and Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic.
    • Information by UniProt
    • Database links
    • Alternative names
      • AAC 11 antibody
      • AAC-11 antibody
      • AAC11 antibody
      • Antiapoptosis clone 11 protein antibody
      • API 5 antibody
      • API-5 antibody
      • api5 antibody
      • API5 like 1 antibody
      • API5_HUMAN antibody
      • API5L1 antibody
      • Apoptosis inhibitor 5 antibody
      • Cell migration inducing gene 8 protein antibody
      • Cell migration-inducing gene 8 protein antibody
      • Fibroblast growth factor 2 interacting factor 2 antibody
      • Fibroblast growth factor 2-interacting factor antibody
      • FIF antibody
      • MIG 8 antibody
      • MIG8 antibody
      • Migration inducing protein MIG8 antibody
      • Protein XAGL antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma (left) and mouse teratoma (right) tissues labelling Apoptosis inhibitor 5 with ab99308 at 1/5000 (0.2µg/mg). Detection: DAB.
    • anti Apoptosis inhibitor 5 (ab99307), at 0.4 µg/ml, staining Apoptosis inhibitor 5 in HeLa whole cell lysate immunoprecipitated using ab99308 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with an exposure time of 1 second.

    References

    ab99308 has not yet been referenced specifically in any publications.

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