Overview

  • Product nameAnti-APPBP1 antibody
    See all APPBP1 primary antibodies
  • Description
    Mouse monoclonal to APPBP1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-535 of Human APPBP1

Properties

Applications

Our Abpromise guarantee covers the use of ab56420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRegulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
    • Tissue specificityUbiquitous in fetal tissues. Expressed throughout the adult brain.
    • PathwayProtein modification; protein neddylation.
    • Sequence similaritiesBelongs to the ubiquitin-activating E1 family. ULA1 subfamily.
    • Cellular localizationCell membrane. Colocalizes with APP in lipid rafts.
    • Information by UniProt
    • Database links
    • Alternative names
      • 59 kDa antibody
      • A 116A10.1 antibody
      • Amyloid beta precursor protein binding protein 1 59kD antibody
      • Amyloid beta precursor protein binding protein 1 59kDa antibody
      • Amyloid beta precursor protein binding protein 1 antibody
      • Amyloid beta precursor protein binding protein 1, 59 kDa antibody
      • Amyloid beta precursor protein-binding protein 1 antibody
      • Amyloid protein binding protein 1 antibody
      • Amyloid protein-binding protein 1 antibody
      • APP BP1 antibody
      • APP-BP1 antibody
      • APPBP 1 antibody
      • APPBP1 antibody
      • HPP 1 antibody
      • HPP1 antibody
      • NAE 1 antibody
      • NAE1 antibody
      • NEDD8 activating enzyme E1 regulatory subunit antibody
      • NEDD8 activating enzyme E1 subunit 1 antibody
      • NEDD8 activating enzyme E1 subunit antibody
      • NEDD8-activating enzyme E1 regulatory subunit antibody
      • Proto oncogene protein 1 antibody
      • Proto-oncogene protein 1 antibody
      • Protooncogene protein 1 antibody
      • ula 1 antibody
      • ULA1_HUMAN antibody
      see all

    Anti-APPBP1 antibody images



    • Predicted band size : 60 kDa
      APPBP1 antibody (ab56420) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-APPBP1 antibody (ab56420)

    ab56420 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"