Overview

  • Product nameAnti-APPL antibody
    See all APPL primary antibodies
  • Description
    Rabbit polyclonal to APPL
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 467-516 (GQAKAFGQGG RRTNPFGESG GSTKSETEDS ILHQLFIVRF LGSMEVKSDD) of Human APPL (NP_036228).

  • Positive control
    • THP1 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab98312 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 80 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionRequired for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
  • Tissue specificityHigh levels in heart, ovary, pancreas and skeletal muscle.
  • Sequence similaritiesContains 1 PH domain.
    Contains 1 PID domain.
  • DomainOverexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationEarly endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adapter protein containing PH domain antibody
    • Adaptor Protein Containing pH Domain antibody
    • Adaptor protein containing pH domain PTB domain and leucine zipper motif 1 antibody
    • Adaptor protein containing pH domain PTB domain and leucine zipper motif antibody
    • AKT2 INTERACTOR antibody
    • APPL 1 antibody
    • Appl1 antibody
    • DCC interacting protein 13 alpha antibody
    • DCC-interacting protein 13-alpha antibody
    • DIP 13 alpha antibody
    • DIP13 alpha antibody
    • Dip13-alpha antibody
    • DIP13alpha antibody
    • DP13A_HUMAN antibody
    • KIAA1428 antibody
    • PTB domain and leucine zipper motif 1 antibody
    • PTB Domain and Leucine Zipper Motif antibody
    • Signaling adaptor protein DIP13alpha antibody
    see all

Anti-APPL antibody images

  • Anti-APPL antibody (ab98312) at 1 µg/ml + THP1 cell lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 80 kDa

References for Anti-APPL antibody (ab98312)

ab98312 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"