Overview

  • Product name
  • Description
    Rabbit polyclonal to Aquaporin 0
  • Specificity
    ab15077 recognises aquaporin 0.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Cow
  • Immunogen

    A 17 AA synthetic peptide within the carboxy terminal domain of human Aquaporin 0.

Properties

Applications

Our Abpromise guarantee covers the use of ab15077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notes
    ELISA: Use at a concentration of 0.5 - 1 µg/ml.
    WB: Use at a concentration of 1 - 10 µg/ml with ECL detection. Predicted molecular weight: 28 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.
    • Tissue specificity
      Major component of lens fiber gap junctions.
    • Involvement in disease
      Cataract 15, multiple types
    • Sequence similarities
      Belongs to the MIP/aquaporin (TC 1.A.8) family.
    • Domain
      Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.
    • Post-translational
      modifications
      Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.
    • Cellular localization
      Cell membrane. Cell junction > gap junction.
    • Information by UniProt
    • Database links
    • Alternative names
      • AQP 0 antibody
      • AQP0 antibody
      • Aquaporin antibody
      • Aquaporin-0 antibody
      • Aquaporin0 antibody
      • Lens fiber major intrinsic protein antibody
      • LIM 1 antibody
      • LIM1 antibody
      • Major intrinsic protein 26kD antibody
      • Major intrinsic protein of lens fiber antibody
      • MIP 26 antibody
      • mip antibody
      • MIP_HUMAN antibody
      • MIP26 antibody
      • MP 26 antibody
      • MP26 antibody
      • PALM antibody
      see all

    References

    This product has been referenced in:
    • Chaffee BR  et al. FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol 410:150-163 (2016). Read more (PubMed: 26764128) »
    • Tan H  et al. Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats. J Neuroinflammation 11:93 (2014). Read more (PubMed: 24884762) »

    See all 4 Publications for this product

    Customer reviews and Q&As

    いつもお世話になっております。 この度はお問合せいただきましてありがとうございます。 申し訳ありませんが、ab15077のpositive controlを取り扱いしておりません。しかしながら、bovine lens fiberはpositive controlとしてご使用できます。 もしよければ、この抗体や、似ているクローンの文献情報は以下に添付いたします。 Molecular Vision 2003; 9:497-501 [http://www.molvis.org/mo...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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