Anti-Aquaporin 4 antibody (ab15118)

Overview

  • Product nameAnti-Aquaporin 4 antibody
    See all Aquaporin 4 primary antibodies
  • Description
    Rabbit polyclonal to Aquaporin 4
  • SpecificityThe 17 AA rat AQP41 peptide was found to be unique to AQP4.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide (Rat) conjugated to KLH (C terminal).

  • Positive control
    • Rat cerebellum.

Properties

Applications

Our Abpromise guarantee covers the use of ab15118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: 1/10000 - 1/50000.
    WB: 1/1000 - 1/5000. Predicted molecular weight: 35 kDa. Note: Recommend the use of 0.5-1% milk in all primary/secondary antibody-enzyme conjugate incubations in order to suppress non-specific bands.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionForms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
    • Tissue specificityBrain - muscle >> heart, kidney, lung, and trachea.
    • Sequence similaritiesBelongs to the MIP/aquaporin (TC 1.A.8) family.
    • DomainAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
    • Post-translational
      modifications
      Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40%.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AQP 4 antibody
      • AQP-4 antibody
      • AQP4 antibody
      • AQP4_HUMAN antibody
      • Aquaporin type 4 antibody
      • Aquaporin-4 antibody
      • Aquaporin4 antibody
      • HMIWC 2 antibody
      • HMIWC2 antibody
      • Mercurial insensitive water channel antibody
      • Mercurial-insensitive water channel antibody
      • MGC22454 antibody
      • MIWC antibody
      • WCH 4 antibody
      • WCH4 antibody
      see all

    References for Anti-Aquaporin 4 antibody (ab15118)

    ab15118 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. I can't find any reference to a glycosylated 52KD form. I checked with our source for this antibody and he said he did not either; he "found literature on the Internet that glycosylation of Aquaporin 4 can occur at a motif n...

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    Dear Dr Lovatt; Thank you for your enquiry. We do not have any specific information regarding the epitope that this product recognises. The aa sequence indicates an intracellular epitope. If you need any further assistance please do not hesitate to ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"