The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2 - 10 µg/ml.
Use a concentration of 0.5 - 1 µg/ml.
Use a concentration of 0.05 - 0.1 µg/ml. Predicted molecular weight: 29 kDa.
Use at an assay dependent concentration. PubMed: 21704616
Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).
Involvement in disease
Keratoderma, palmoplantar, Bothnian type
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Tong L et al. Fibroblast Growth Factor-10 (FGF-10) Mobilizes Lung-resident Mesenchymal Stem Cells and Protects Against Acute Lung Injury. Sci Rep6:21642 (2016).
Read more (PubMed: 26869337) »
Cao Z et al. Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nat Med22:154-62 (2016).
Read more (PubMed: 26779814) »