The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 2 - 10 µg/ml.
Use a concentration of 0.5 - 1 µg/ml.
Use a concentration of 0.05 - 0.1 µg/ml. Predicted molecular weight: 29 kDa.
Use at an assay dependent concentration. PubMed: 21704616
Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723).
Involvement in disease
Keratoderma, palmoplantar, Bothnian type
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).