Ara-adenosine-5'-triphosphate (ara-ATP) (aqueous solution) (ab146748)

Overview

  • Product name
    Ara-adenosine-5'-triphosphate (ara-ATP) (aqueous solution)
  • Description
    Adenosine analog. Poly(A) polymerase substrate. Competitive viral DNA polymerase inhibitor.
  • Alternative names
    • Adenine-arabinofuranoside-5’-triphosphate
    • Adenine-arabinofuranoside-5’-triphosphate, Sodium salt
    • ara-ATP
    • Vidarabine triphosphate
    • Vidarabine triphosphate, Sodium Salt
    see all
  • Biological description

    Adenosine analog. Poly(A) polymerase substrate. Inhibits cleavage and polyadenylation reactions by interacting with the ATP-binding site on poly(A) polymerase. Active form of Vidarabine (Vira-A) (ab143081). Antiviral properties. Competitive viral DNA polymerase inhibitor. Disrupts viral DNA synthesis.

  • Purity
    > 95%

Properties

  • Molecular weight
    507.18
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C10H16N5O13P3
  • CAS Number
    3714-60-1
  • Storage instructions
    Store at -20°C (desiccating conditions).
  • Solubility overview
    Supplied in water (10 mM)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Ghoshal K & Jacob ST Ara-ATP impairs 3'-end processing of pre-mRNAs by inhibiting both cleavage and polyadenylation. Nucleic Acids Res 19:5871-5 (1991). Read more (PubMed: 1719481) »
  • Rose KM & Jacob ST Selective inhibition of RNA polyadenylation by Ara-ATP in vitro: a possible mechanism for antiviral action of Ara-A. Biochem Biophys Res Commun 81:1418-24 (1978). Read more (PubMed: 666826) »
  • Chadwick RG  et al. HBsAg-positive chronic liver disease: inhibition of DNA polymerase activity by vidarabine. Br Med J 2:531-3 (1978). Read more (PubMed: 698557) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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