ω-6 Polyunsaturated fatty acid, precursor of eicosanoids
Biological descriptionMajor precursor in the production of eicosanoids and important cellular signaling mediator. Endogenous free fatty acid released from phospholipids by PLA2. Metabolised by COX, lipoxygenase and cytochrome p450s to form a variety of eicosanoids including PGs and LTs.
Chemical name5Z,8Z,11Z,14Z-Eicosatetraenoic acid
Storage instructionsStore at -20°C (desiccating conditions).
Solubility overviewSupplied in ethanol (250 mg/ml)
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Higuchi Y et al. Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12- lipoxygenase activation in glioma cells. Life Sci80:1856-64 (2007).
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