Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab117435 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Arc antibody (ab85656)

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Constituent: PBS

  • Reconstitution
    Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS.

General Info

  • Alternative names
    • activity regulated cytoskeleton associated protein
    • activity regulated gene 3.1 protein homolog
    • Activity-regulated cytoskeleton-associated protein
    • Activity-regulated gene 3.1 protein homolog
    • Arc
    • ARC/ARG3.1
    • ARC_HUMAN
    • Arg 3.1
    • Arg3.1
    see all
  • Function
    Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration.
  • Sequence similarities
    Belongs to the ARC/ARG3.1 family.
  • Cellular localization
    Cytoplasm > cytoskeleton. Endosome. Cytoplasmic vesicle > secretory vesicle > acrosome. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Cell projection > dendritic spine. Cell junction > synapse. Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail (By similarity). Enriched on the plasma membrane.
  • Information by UniProt

References

This product has been referenced in:
  • Gilbert MT & Soderstrom K Novel song-stimulated dendritic spine formation and Arc/Arg3.1 expression in zebra finch auditory telencephalon are disrupted by cannabinoid agonism. Brain Res 1541:9-21 (2013). Read more (PubMed: 24134952) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for contacting us. I was able to have the blocking peptide for ab85656 added to our catalog as ab117435. I hope this helps, please let me know if you need any additional assistance.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up