Anti-Argininosuccinate Lyase antibody (ab96215)

Overview

  • Product nameAnti-Argininosuccinate Lyase antibody
    See all Argininosuccinate Lyase primary antibodies
  • Description
    Rabbit polyclonal to Argininosuccinate Lyase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 86-335 of Human Argininosuccinate Lyase.

  • Positive control
    • 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cells

Properties

Applications

Our Abpromise guarantee covers the use of ab96215 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 52 kDa.

Target

  • PathwayAmino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.
    Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1.
  • Involvement in diseaseDefects in ASL are the cause of arginosuccinicaciduria (ARGINSA) [MIM:207900]. Arginosuccinicaciduria is an autosomal recessive disorder of the urea cycle. The disease is characterized by mental and physical retardation, liver enlargement, skin lesions, dry and brittle hair showing trichorrhexis nodosa microscopically and fluorescing red, convulsions, and episodic unconsciousness.
  • Sequence similaritiesBelongs to the lyase 1 family. Argininosuccinate lyase subfamily.
  • Post-translational
    modifications
    Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity.
  • Information by UniProt
  • Database links
  • Alternative names
    • Argininosuccinase antibody
    • Argininosuccinate lyase antibody
    • Arginosuccinase antibody
    • ARLY_HUMAN antibody
    • ASAL antibody
    • ASL antibody
    • EC 4.3.2.1 antibody
    see all

Anti-Argininosuccinate Lyase antibody images

  • Anti-Argininosuccinate Lyase antibody (ab96215) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 52 kDa

References for Anti-Argininosuccinate Lyase antibody (ab96215)

ab96215 has not yet been referenced specifically in any publications.

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