The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 150 kDa (predicted molecular weight: 132 kDa).
FunctionGTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Tissue specificityExpressed predominantly in the brain. Lower expression is found in lymph nodes.
Involvement in diseaseNote=A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes.