Overview

  • Product name
  • Description
    Rabbit polyclonal to ARHGAP21
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: VPPCLTTSAP LIRRQLSHDH ESVGPPSLDA QPNSKTERSK SYDEGLDDYR EDAKLSFKHV SSLKGIKIAD SQKSSEDSGS RKDSSSEVFS DAAKEG, corresponding to amino acids 840-935 of Human ARHGAP21.

  • Positive control
    • Human gall bladder tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
  • Tissue specificity
    Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.
  • Sequence similarities
    Contains 1 PDZ (DHR) domain.
    Contains 1 PH domain.
    Contains 1 Rho-GAP domain.
  • Cellular localization
    Golgi apparatus membrane. Cell junction. Cytoplasmic vesicle membrane. Cytoplasm > cytoskeleton. Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
  • Information by UniProt
  • Database links
  • Alternative names
    • Arhgap21 antibody
    • KIAA1424 antibody
    • RHG21_HUMAN antibody
    • Rho GTPase-activating protein 10 antibody
    • Rho GTPase-activating protein 21 antibody
    • Rho-type GTPase-activating protein 21 antibody
    see all

Images

  • ab122350, at 1/200 dilution, staining ARHGAP21 in paraffin-embedded Human gall bladder tissue by Immunohistochemistry.

References

ab122350 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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