Overview

  • Product nameAnti-ARHGEF1 antibody
    See all ARHGEF1 primary antibodies
  • Description
    Rabbit polyclonal to ARHGEF1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 163-192 of Human ARHGEF1 (NP_945328.1, NP_945353.1, NP_004697.2).

  • Positive control
    • CEM cell line lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab123582 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab123582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 102 kDa.

Target

  • FunctionSeems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
  • Tissue specificityUbiquitously expressed.
  • Sequence similaritiesContains 1 DH (DBL-homology) domain.
    Contains 1 PH domain.
    Contains 1 RGSL (RGS-like) domain.
  • DomainThe RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.
    The DH domain is involved in interaction with CCPG1.
  • Post-translational
    modifications
    Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2.
  • Cellular localizationCytoplasm. Membrane. Translocated to the membrane by activated GNA13 or LPA stimulation.
  • Information by UniProt
  • Database links
  • Alternative names
    • 115 kD protein antibody
    • 115 kDa guanine nucleotide exchange factor antibody
    • ARHG1_HUMAN antibody
    • ARHGEF 1 antibody
    • ARHGEF1 antibody
    • GEF 1 antibody
    • GEF1 antibody
    • LBCL 2 antibody
    • LBCL2 antibody
    • LSC antibody
    • Lsc homolog antibody
    • p115 RhoGEF antibody
    • p115-RhoGEF antibody
    • p115RhoGEF antibody
    • Rho guanine nucleotide exchange factor (GEF) 1 antibody
    • Rho guanine nucleotide exchange factor 1 antibody
    • Sub1.5 antibody
    see all

Anti-ARHGEF1 antibody images

  • Anti-ARHGEF1 antibody (ab123582) at 1/100 dilution + CEM cell line lysate at 35 µg

    Predicted band size : 102 kDa

References for Anti-ARHGEF1 antibody (ab123582)

ab123582 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"