Overview

  • Product name
  • Description
    Rabbit polyclonal to ARHGEF11
  • Specificity
    This antibody detects endogenous levels of total ARHGEF11 protein.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the N terminal region of Human ARHGEF11.

  • Positive control
    • A549 and COLO cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab110059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 168 kDa.

Target

  • Function
    May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
  • Tissue specificity
    Ubiquitously expressed.
  • Sequence similarities
    Contains 1 DH (DBL-homology) domain.
    Contains 1 PDZ (DHR) domain.
    Contains 1 PH domain.
    Contains 1 RGSL (RGS-like) domain.
  • Domain
    The poly-Pro region is essential for plasma membrane localization upon stimulation.
  • Cellular localization
    Cytoplasm. Membrane. Translocated to the membrane upon stimulation.
  • Information by UniProt
  • Database links
  • Alternative names
    • ARHGB_HUMAN antibody
    • ARHGEF 11 antibody
    • ARHGEF11 antibody
    • DKFZp667F1223 antibody
    • Glutamate transporter EAAT4 associated protein 48 antibody
    • GTRAP 48 antibody
    • GTRAP48 antibody
    • KIAA0380 antibody
    • OTTHUMP00000038716 antibody
    • OTTHUMP00000038717 antibody
    • PDZ RHOGEF antibody
    • PDZ-RhoGEF antibody
    • Rho guanine exchange factor (GEF) 11 antibody
    • Rho guanine nucleotide exchange factor (GEF) 11 antibody
    • Rho guanine nucleotide exchange factor 11 antibody
    • RhoA specific guanine nucleotide exchange factor antibody
    • RhoGEF glutamate transport modulator antibody
    see all

Images

  • All lanes : Anti-ARHGEF11 antibody (ab110059) at 1/500 dilution

    Lane 1 : A549 cell extract
    Lane 2 : COLO cell extract
    Lane 3 : COLO cell extract with immunizing peptide

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 168 kDa

References

ab110059 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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