Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 1 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionGuanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.
    • Sequence similaritiesBelongs to the MCF2 family.
      Contains 1 CRAL-TRIO domain.
      Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 SH3 domain.
      Contains 1 spectrin repeat.
    • DomainThe CRAL-TRIO domain is involved in interaction with inositol phospholipids.
      The DH domain is involved in interaction with CCPG1.
    • Cellular localizationCytoplasm. Cell membrane.
    • Target information above from: UniProt accession O15068 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • ARHGEF 14 antibody
      • DBL''s big sister antibody
      • DBS antibody
      • FLJ12122 antibody
      • Guanine nucleotide exchange factor DBS antibody
      • KIAA0362 antibody
      • MCF 2L antibody
      • MCF.2 cell line derived transforming sequence like antibody
      • MCF.2 transforming sequence-like antibody
      • MCF2 like protein antibody
      • MCF2 transforming sequence like protein antibody
      • MCF2-transforming sequence-like protein antibody
      • Mcf2l antibody
      • MCF2L_HUMAN antibody
      • OST antibody
      • OST oncogene antibody
      see all

    Anti-ARHGEF14 antibody images

    • ARHGEF14 antibody (ab57401) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human tonsil.
    • Western blot against tagged recombinant protein immunogen using ab57401 ARHGEF14 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-ARHGEF14 antibody (ab57401)

    ab57401 has not yet been referenced specifically in any publications.

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