Overview

  • Product name
  • Description
    Rabbit polyclonal to ARIH2
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residue 100 and 150 of Human ARIH2 (NP_006312.1).

  • Positive control
    • HeLa whole cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab101982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
    • Tissue specificity
      Widely expressed with higher expression in granulocytes.
    • Pathway
      Protein modification; protein ubiquitination.
    • Sequence similarities
      Belongs to the RBR family. Ariadne subfamily.
      Contains 1 IBR-type zinc finger.
      Contains 2 RING-type zinc fingers.
    • Domain
      RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis.
    • Post-translational
      modifications
      Ubiquitinated. Ubiquitination promotes proteasomal degradation.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Nucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • HT005 antibody
      • all trans retinoic acid inducible RING finger antibody
      • Ari 2 antibody
      • Ari-2 antibody
      • ARI2 antibody
      • ARI2_HUMAN antibody
      • Ariadne 2 antibody
      • Ariadne 2 protein homolog antibody
      • ariadne homolog 2 (Drosophila) antibody
      • ariadne homolog 2 antibody
      • Ariadne RBR E3 ubiquitin protein ligase 2 antibody
      • ARIH 2 antibody
      • Arih2 antibody
      • E3 ubiquitin protein ligase ARIH2 antibody
      • E3 ubiquitin-protein ligase ARIH2 antibody
      • protein ariadne 2 homolog antibody
      • Protein ariadne-2 homolog antibody
      • Triad 1 antibody
      • TRIAD1 antibody
      • Triad1 protein antibody
      • UIP48 antibody
      see all

    Images

    • Detection of ARIH2 by Western Blot of Immunprecipitate.
      An antibody to ARIH2, at 0.4 µg/ml, staining ARIH2 in HeLa whole cell lysate immunoprecipitated using ab101982 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with an exposure time of 30 seconds.

    References

    ab101982 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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