Biological descriptionPartial dopamine D2 agonist. Ki (nM) values are 265 (D1), 0.34 (D2), 0.8 (D3), 44 (D4), 1.7 (5-HT1A), 3.4 (5-HT2A), 15 (5-HT2C), 214 (5-HT6), 39 (5-HT7), 57 (α1), 791 (α2), 61 (H1) and >1000 (M1). Antipsychotic and antidepressant activity. Centrally active following oral administration.
Storage instructionsStore at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 50 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Segnitz N et al. Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain. Psychopharmacology (Berl)217:127-42 (2011).
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