Purification notesThis antibody was purified through a protein G column and eluted out with both high and low pH buffers. It was neutralized immediately after elution, followed by dialysis against PBS.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Detects a band of approximately 74 kDa (predicted molecular weight: 74 kDa).
Use at an assay dependent concentration.
FunctionInvolved in tolerance to glucose starvation. Phosphorylates ATM. Suppresses Fas-induced apoptosis by phosphorylation of CASP6, thus suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
Tissue specificityExpressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver.
Sequence similaritiesBelongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 protein kinase domain.
Post-translational modificationsUbiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X.
ab37641, at 1/50 dilution, staining ARK5 in Human breast carcinoma by Immunohistochemistry, Formalin fixed, Paraffin embedded tissue. ab37641 was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
References for Anti-ARK5 antibody (ab37641)
has not yet been referenced specifically in any publications.
Publishing research using ab37641? Please let us know so that we can cite the reference in this datasheet.
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