• Product nameAnti-ARL6 antibody
    See all ARL6 primary antibodies
  • Description
    Rabbit polyclonal to ARL6
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to N terminal residues of human ARL6.



Our Abpromise guarantee covers the use of ab55821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.


  • FunctionInvolved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.
  • Involvement in diseaseDefects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3) [MIM:209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease.
    Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55) [MIM:613575]. RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Sequence similaritiesBelongs to the small GTPase superfamily. Arf family.
  • Cellular localizationCell projection > cilium membrane. Cytoplasm > cytoskeleton > cilium axoneme. Cytoplasm > cytoskeleton > cilium basal body. Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ADP ribosylation factor like 6 antibody
    • ADP ribosylation factor like protein 6 antibody
    • ADP-ribosylation factor-like protein 6 antibody
    • Arl6 antibody
    • ARL6_HUMAN antibody
    • Bardet Biedl syndrome 3 protein antibody
    • Bardet-Biedl syndrome 3 protein antibody
    • BBS3 antibody
    • MGC32934 antibody
    see all

References for Anti-ARL6 antibody (ab55821)

ab55821 has not yet been referenced specifically in any publications.

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