The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 20 µg/ml.
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 27 kDa (predicted molecular weight: 23 kDa).
Use at an assay dependent concentration.
FunctionMay be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
Tissue specificityExpressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart.
Sequence similaritiesBelongs to the ARL6ip family.
Developmental stageDown-regulated during myeloid differentiation.
Cellular localizationEndomembrane system. Predominantly localized to intracytoplasmic membranes.