Overview

  • Product name
  • Description
    Rabbit polyclonal to ARMET
  • Tested applications
    Suitable for: WB, ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    12 amino acid peptide from near the amino terminus of human MANF.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Purified IgA
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab67203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 20 kDa).
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Function
    Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
  • Sequence similarities
    Belongs to the ARMET family.
  • Domain
    The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
  • Post-translational
    modifications
    May contain sialic acid residues.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Arginine rich mutated in early stage tumors antibody
    • Arginine rich protein antibody
    • Arginine-rich protein antibody
    • ARMET antibody
    • ARMET protein antibody
    • ARP antibody
    • Manf antibody
    • MANF_HUMAN antibody
    • Mesencephalic astrocyte derived neurotrophic factor antibody
    • Mesencephalic astrocyte-derived neurotrophic factor antibody
    • MGC142148 antibody
    • MGC142150 antibody
    • Protein ARMET antibody
    see all

Images

  • Lane 1 : Anti-ARMET antibody (ab67203) at 1 µg/ml
    Lane 2 : Anti-ARMET antibody (ab67203) at 2 µg/ml

    Lane 1 : rat brain tissue lysate
    Lane 2 : rat brain tissue lysate


    Predicted band size : 20 kDa
  • Ab67203 (2.5 ug/ml) staining of ARMET in human brain tissue by IHC.
  • Immunofluorescence of MANF in Human Brain cells using ab67203 at 20 ug/ml.

References

This product has been referenced in:
  • Chen L  et al. Identification of MANF as a protein interacting with RTN1-C. Acta Biochim Biophys Sin (Shanghai) 47:91-7 (2015). Read more (PubMed: 25543119) »
  • Di Penta A  et al. A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. PLoS One 8:e83119 (2013). WB ; Mouse . Read more (PubMed: 24349442) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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