Overview

  • Product name
  • Description
    Goat polyclonal to Aromatase
  • Host species
    Goat
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Cynomolgus monkey
  • Immunogen

    Synthetic peptide:

    C-HDLSLHPDETKN

    , corresponding to internal sequence amino acids 475-486 of Human Aromatase (NP_000094.2; NP_112503.1).

  • Positive control
    • Human Placenta lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notes
    Peptide ELISA: Antibody detection limit dilution 1/128000.
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
    • Tissue specificity
      Brain, placenta and gonads.
    • Involvement in disease
      Defects in CYP19A1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.
      Defects in CYP19A1 are the cause of aromatase deficiency (AROD) [MIM:107910]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
    • Sequence similarities
      Belongs to the cytochrome P450 family.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ARO antibody
      • ARO1 antibody
      • Aromatase antibody
      • CP19A_HUMAN antibody
      • CPV1 antibody
      • CYAR antibody
      • CYP19 antibody
      • Cyp19a1 antibody
      • CYPXIX antibody
      • Cytochrome P-450AROM antibody
      • Cytochrome P450 19A1 antibody
      • Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody
      • Cytochrome P450, subfamily XIX (aromatization of androgens) antibody
      • Estrogen synthase antibody
      • Estrogen synthetase antibody
      • Flavoprotein linked monooxygenase antibody
      • MGC104309 antibody
      • Microsomal monooxygenase antibody
      • OTTHUMP00000162543 antibody
      • OTTHUMP00000198350 antibody
      • P 450AROM antibody
      see all

    Images

    • Anti-Aromatase antibody (ab77377) at 0.1 µg/ml + Human Placenta lysate (in RIPA buffer) at 35 µg

      Predicted band size: 58 kDa
      Observed band size: 58 kDa



      Primary incubation was 1 hour. Detected by chemiluminescence.

    References

    ab77377 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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