Anti-ARP19 (phospho S109) antibody - C-terminal (ab196340)

Overview

  • Product name
    Anti-ARP19 (phospho S109) antibody - C-terminal
    See all ARP19 primary antibodies
  • Description
    Rabbit polyclonal to ARP19 (phospho S109) - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Xenopus tropicalis
  • Immunogen

    Synthetic peptide corresponding to Xenopus tropicalis ARP19 (C terminal) (phospho S109).
    Database link: Q28GU6

Properties

Applications

Our Abpromise guarantee covers the use of ab196340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 13 kDa.

Target

  • Function
    Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.
  • Sequence similarities
    Belongs to the endosulfine family.
  • Post-translational
    modifications
    Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated by PKA.
    Isoform ARPP-16 contains a N-acetylmethionine at position 1.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
    • Alternative names
      • ARP19_HUMAN antibody
      • ARPP-19 antibody
      • Arpp19 antibody
      • cAMP-regulated phosphoprotein 19 antibody

    References

    ab196340 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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