Overview

  • Product nameAnti-ARSB antibody
    See all ARSB primary antibodies
  • Description
    Rabbit polyclonal to ARSB
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Horse, Guinea pig, Cow, Cat, Dog, Human, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 300-349 (TDNGGQTRSG GNNWPLRGRK GTLWEGGIRG TGFVASPLLK QKGVKSRELM) of Mouse ARSB (NP_033842).

  • Positive control
    • Mouse kidney lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab115894 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Involvement in diseaseDefects in ARSB are the cause of mucopolysaccharidosis type 6 (MPS6) [MIM:253200]; also known as Maroteaux-Lamy syndrome. MPS6 is an autosomal recessive lysosomal storage disease characterized by intracellular accumulation of dermatan sulfate. Clinical features can include abnormal growth, short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly, and cardiac abnormalities. A wide variation in clinical severity is observed.
    Arylsulfatase B activity is defective in multiple sulfatase deficiency (MSD) [MIM:272200]. MSD is a disorder characterized by decreased activity of all known sulfatases. MSD is due to defects in SUMF1 resulting in the lack of post-translational modification of a highly conserved cysteine into 3-oxoalanine. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay.
  • Sequence similaritiesBelongs to the sulfatase family.
  • Post-translational
    modifications
    The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).
  • Cellular localizationLysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Arsb antibody
    • ARSB_HUMAN antibody
    • Arylsulfatase B antibody
    • ArylsulfataseB antibody
    • ASB antibody
    • G4S antibody
    • MPS6 antibody
    • N acetylgalactosamine 4 sulfatase antibody
    • N-acetylgalactosamine-4-sulfatase antibody
    see all

Anti-ARSB antibody images

  • Anti-ARSB antibody (ab115894) at 1 µg/ml + Mouse kidney lysate at 10 µg

    Predicted band size : 60 kDa

References for Anti-ARSB antibody (ab115894)

ab115894 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"