Overview

  • Product name
    AS-041164
  • Description
    Potent and selective PI3Kγ inhibitor
  • Biological description
    Potent PI3K inhibitor with selectivity for PI3Kγ (IC50 = 70 nM), compared to PI3Kα, β and δ (IC50 values are 240 nM, 1.45 and 1.70 μM, respectively). Shows little or no activity against 38 other common kinases. Blocks neutrophil migration. Active in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Ferrandi C  et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther 322:923-30 (2007). Read more (PubMed: 17526805) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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