Biological descriptionPotent, selective and ATP-competitive PI3Kγ inhibitor (IC50 values are 33 nM (PI3Kγ), 935 nM (PI3Kα) and 20 μM (PI3Kβ and PI3Kδ)). Active in vivo.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Graves BM et al. Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes. J Biomed Sci19:59 (2012).
Read more (PubMed: 22715995) »
Pomel V et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem49:3857-71 (2006).
Read more (PubMed: 16789742) »
Condliffe AM et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood106:1432-40 (2005).
Read more (PubMed: 15878979) »