Overview

  • Product nameAS-604850
  • Description
    Selective, ATP-competitive PI3Kγ inhibitor
  • Biological descriptionSelective, ATP-competitive PI3Kγ inhibitor (IC50 values are 0.25 (PI3Kγ), >20 (PI3Kδ and PI3Kβ), and 4.5 µM (PI3Kα)). Pharmacologically active in vivo.
  • Purity> 98%

Properties

    References for AS-604850 (ab120935)

    This product has been referenced in:
    • Hohenester S  et al. Phosphatidylinositol-3-kinase p110? contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J Hepatol 53:918-26 (2010). Read more (PubMed: 20675006) »
    • Hasan AM  et al. Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. Int Immunopharmacol 10:1017-21 (2010). Read more (PubMed: 20685403) »
    • Camps M  et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med 11:936-43 (2005). Read more (PubMed: 16127437) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"