Anti-ASB2 antibody (ab13710)

Overview

  • Product nameAnti-ASB2 antibody
    See all ASB2 primary antibodies
  • Description
    Rabbit polyclonal to ASB2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    This product was produced with the following immunogens:
    Synthetic peptide corresponding to Human ASB2 aa 79-93.
    Sequence:

    TMIKEGKNLAEPNKEGWLP



    Synthetic peptide corresponding to Human ASB2 aa 348-368.
    Sequence: NTPLAPERARLYEDRRSSALY

  • Positive control
    • Human spleen lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab13710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 65 kDa.

Target

  • RelevanceThe ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • Ankyrin repeat and SOCS box 2 containing protein antibody
    • Ankyrin repeat and SOCS box containing 2 antibody
    • Ankyrin repeat and SOCS box containing protein 2 antibody
    • Ankyrin repeat and SOCS box containing protein 2a antibody
    • Ankyrin repeat and SOCS box protein 2 antibody
    • Ankyrin repeat containing protein ASB2 antibody
    • ASB 2 antibody
    see all

Anti-ASB2 antibody images

References for Anti-ASB2 antibody (ab13710)

ab13710 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry
Sample Mouse Cultured Cells (RAW 264.7)
Specification RAW 264.7
Fixative Paraformaldehyde
Permeabilization Yes - 0.1% Triton-X100 in 2% BSA for 15min
Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2% · Temperature: 22°C
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Dr. Mahesh Shivananjappa

Verified customer

Submitted May 19 2012

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Application Flow Cytometry
Sample Human Cell (Platelets)
Specification Platelets
Preparation Cell harvesting/tissue preparation method: PL were isolated spinning Platelet rich plasma on Histopaque
Sample buffer: PBS
Fixation Paraformaldehyde
Permeabilization Yes - 0.1% Triton-X100 in 2% BSA for 15min
Gating Strategy Platelets
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Abcam user community

Verified customer

Submitted Dec 22 2010

Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (PMN)
Specification PMN
Fixative Formaldehyde
Permeabilization Yes - 0.1% Triton-X
Blocking step BSA as blocking agent for 10 minute(s) · Concentration: 2% · Temperature: 22°C
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Verified customer

Submitted Feb 18 2010

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"