Overview

  • Product nameAnti-ASB8 antibody
    See all ASB8 primary antibodies
  • Description
    Mouse monoclonal to ASB8
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 179-289 of Human ASB8 (NP_077000) with a proprietary tag.

  • Positive control
    • Recombinant Protein. Human pancreas tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab118338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 µg/ml. Do not perform antigen retrieval. Place sample in 1X citrate buffer (pH 6.0) in pressure cooker under 125 °C for 4min and under 90 °C for 45min, cool sample subsequently.

Target

  • FunctionMay be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • Tissue specificityHighest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 4 ANK repeats.
    Contains 1 SOCS box domain.
  • DomainThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ankyrin repeat and SOCS box containing 8 antibody
    • Ankyrin repeat and SOCS box protein 8 antibody
    • ASB 8 antibody
    • ASB-8 antibody
    • ASB8 antibody
    • ASB8_HUMAN antibody
    • FLJ21255 antibody
    • MGC5540 antibody
    • OTTHUMP00000237000 antibody
    • OTTHUMP00000237001 antibody
    • OTTHUMP00000237007 antibody
    • OTTHUMP00000237009 antibody
    • OTTHUMP00000237010 antibody
    • PP14212 antibody
    see all

Anti-ASB8 antibody images

  • ab118338 at 3 µg/ml staining ASB8 in Formalin-Fixed, Paraffin-Embedded Human Pancreas tissue by Immunohistochemistry.

References for Anti-ASB8 antibody (ab118338)

ab118338 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"