FunctionHistone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.
Tissue specificityHighly expressed in testis and at lower levels in colon, small intestine and thymus.
Sequence similaritiesBelongs to the ASF1 family.
Post-translational modificationsPhosphorylated by TLK1 and TLK2.