Overview

  • Product nameAnti-ASIC beta antibody
  • Description
    Guinea pig polyclonal to ASIC beta
  • Tested applicationsSuitable for: IHC-Frmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide:

    AGSELDEGDDSPRDLV

    , corresponding to amino acids 3-18 of Rat ASIC beta.

  • Positive control
    • Spinal cord.

Properties

Applications

Our Abpromise guarantee covers the use of ab10355 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr
  • Application notesIHC-Fr: 1/1000. Staining was blocked by preabsorption with the cognate peptide.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceProton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sensory neurons. ASIC-beta, an ASIC splice variant contains a unique N-terminal 172 aa, as well as unique 5' and 3' untranslated sequence. ASIC-beta, unlike ASIC and DRASIC, is found only in a subset of small and large diameter sensory neurons and is absent from sympathetic neurons or the central nervous system. ASIC-beta forms a functional channel with electrophysiological properties distinct from ASIC and DRASIC. The pH dependency and sensitivity to amiloride of ASIC-beta is similar to that described for ASIC, but unlike ASIC, the channel is not permeable to calcium, nor are ASIC-beta-mediated currents inhibited by extracellular calcium. The unique distribution of ASIC-beta suggests that it may play a specialized role in sensory neuron function.

    References for Anti-ASIC beta antibody (ab10355)

    ab10355 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"