Overview

  • Product nameAnti-ASPA antibody
    See all ASPA primary antibodies
  • Description
    Goat polyclonal to ASPA
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    TLSAKSIRSTLH

    by a Cysteine residue linker, corresponding to C terminal amino acids 301-312 of Mouse ASPA (NP_075602.2).

  • Positive control
    • Mouse and Rat kidney lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab112530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa). For 1 hour.

Target

  • FunctionCatalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
  • Tissue specificityBrain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.
  • Involvement in diseaseDefects in ASPA are the cause of Canavan disease (CAND) [MIM:271900]; also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average.
  • Sequence similaritiesBelongs to the AspA/AstE family. Aspartoacylase subfamily.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACY 2 antibody
    • ACY-2 antibody
    • ACY2 antibody
    • ACY2_HUMAN antibody
    • Aminoacylase 2 antibody
    • Aminoacylase-2 antibody
    • Aminoacylase2 antibody
    • ASP antibody
    • ASPA antibody
    • Aspartoacylase (aminoacylase 2, Canavan disease) antibody
    • Aspartoacylase (Canavan disease) antibody
    • Aspartoacylase antibody
    • NUR 7 antibody
    • NUR7 antibody
    • OTTMUSP00000006437 antibody
    • RP23-213I10.1 antibody
    • Small lethargic antibody
    see all

Anti-ASPA antibody images

  • Anti-ASPA antibody (ab112530) at 0.01 µg/ml + Mouse Kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 35 kDa

References for Anti-ASPA antibody (ab112530)

ab112530 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"