Overview

  • Product nameAnti-ASS1 antibody
    See all ASS1 primary antibodies
  • Description
    Rabbit polyclonal to ASS1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant protein fragment with a sequence corresponding to a region within amino acids 155 and 410 of Human ASS1 (NP_446464).

  • Positive control
    • A431 cell lysate, mixed OVCA

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab95964 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 47 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • PathwayAmino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
    Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.
  • Involvement in diseaseDefects in ASS1 are the cause of citrullinemia type 1 (CTLN1) [MIM:215700]. Citrullinemia belongs to the urea cycle disorders. It is an autosomal recessive disease characterized primarily by elevated serum and urine citrulline levels. Ammonia intoxication is another manifestation. CTLN1 usually manifests in the first few days of life. Affected infants appear normal at birth, but as ammonia builds up in the body they present symptoms such as lethargy, poor feeding, vomiting, seizures and loss of consciousness. Less commonly, a milder CTLN1 form can develop later in childhood or adulthood.
  • Sequence similaritiesBelongs to the argininosuccinate synthase family. Type 1 subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • Argininosuccinate synthase 1 antibody
    • Argininosuccinate synthase antibody
    • Argininosuccinate synthetase 1 antibody
    • ASS antibody
    • Ass-1 antibody
    • ass1 antibody
    • ASSA antibody
    • ASSY_HUMAN antibody
    • Citrulline aspartate ligase antibody
    • Citrulline--aspartate ligase antibody
    • CTLN1 antibody
    see all

Anti-ASS1 antibody images

  • Anti-ASS1 antibody (ab95964) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 47 kDa
  • ab95964, at 1/100, staining paraffin-embedded mixed OVCA by Immunohistochemistry.

References for Anti-ASS1 antibody (ab95964)

ab95964 has not yet been referenced specifically in any publications.

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Tissue section if human kidney or liver can be used as positive control for ASS1.

Kidney:

http://www.abcam.com/ab4347: Kidney (human) normal tissue slides
...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"