Overview

  • Product nameAnti-ASXL2 antibody
    See all ASXL2 primary antibodies
  • Description
    Rabbit polyclonal to ASXL2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 575-624 (EEAPVSWEKR PRVTENRQHQ QPFQVSPQPF LNRGDRIQVR KVPPLKIPVS) of Human ASXL2 (NP_060733)

  • Positive control
    • NCI-H226 Cell Lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab106540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 154 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionPutative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility.
  • Involvement in diseaseNote=A chromosomal aberration involving ASXL2 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with MYST3 generates a MYST3-ASXL2 fusion protein.
  • Sequence similaritiesBelongs to the Asx family.
    Contains 1 PHD-type zinc finger.
  • DomainContains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • FormThere are 2 isoforms produced by alternative splicing.
  • Alternative names
    • additional sex combs like 2 (Drosophila) antibody
    • Additional sex combs like 2 antibody
    • Additional sex combs like protein 2 antibody
    • Additional sex combs-like protein 2 antibody
    • ASXH2 antibody
    • ASXL 2 antibody
    • ASXL2 antibody
    • ASXL2_HUMAN antibody
    • DKFZp686C1968 antibody
    • FLJ10898 antibody
    • KIAA1685 antibody
    • Polycomb group protein ASXH2 antibody
    • Putative Polycomb group protein ASXL2 antibody
    see all

Anti-ASXL2 antibody images

  • Anti-ASXL2 antibody (ab106540) at 1 µg/ml + 10 µg NCI-H226 Cell Lysate

    Predicted band size : 154 kDa

References for Anti-ASXL2 antibody (ab106540)

ab106540 has not yet been referenced specifically in any publications.

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