Overview

  • Product nameAnti-AT11A antibody
    See all AT11A primary antibodies
  • Description
    Rabbit polyclonal to AT11A
  • Tested applicationsSuitable for: ELISA, ICC, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal of Human AT11A.

  • Positive control
    • Human testis tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab117577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 129 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionCatalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
  • Sequence similaritiesBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
  • Cellular localizationCell membrane. Early endosome. Recycling endosome. Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.
  • Information by UniProt
  • Database links
  • FormP-type ATPases, such as ATP11A, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes.
  • Alternative names
    • AT11A_HUMAN antibody
    • Atp11a antibody
    • ATPase class VI type 11A antibody
    • ATPase IS antibody
    • ATPIH antibody
    • ATPIS antibody
    • P4-ATPase flippase complex alpha subunit ATP11A antibody
    • Probable phospholipid-transporting ATPase IH antibody
    see all

Anti-AT11A antibody images

  • Immunohistochemical analysis of AT11A expression in Formalin-Fixed, Paraffin-Embedded Human Testis using 5 µg/ml ab117577.

References for Anti-AT11A antibody (ab117577)

ab117577 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"