• Product name
  • Description
    Rabbit polyclonal to Ataxin 1
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 350-400 of Human Ataxin 1 (NP_000323.2).

  • Positive control
    • HeLa whole cell lysate



Our Abpromise guarantee covers the use of ab114045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 10 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
    • Tissue specificity
      Widely expressed throughout the body.
    • Involvement in disease
      Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) [MIM:164400]; also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
    • Sequence similarities
      Belongs to the ATXN1 family.
      Contains 1 AXH domain.
    • Domain
      The AXH domain is required for interaction with CIC.
    • Post-translational
      Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract.
      Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
    • Cellular localization
      Cytoplasm. Nucleus. Colocalizes with USP7 in the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • alternative ataxin1 antibody
      • Ataxin-1 antibody
      • ATX1 antibody
      • ATX1_HUMAN antibody
      • Atxn1 antibody
      • D6S504E antibody
      • OTTHUMP00000016065 antibody
      • SCA1 antibody
      • Spinocerebellar ataxia type 1 protein antibody
      see all


    • Detection of Ataxin 1 in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab114045 at 10 µg/mg lysate for IP. An anti-Ataxin 1 antibody which recognizes a downstream epitope was used at 1 µg/ml for subsequent western blot detection. Detection: Chemiluminescence with exposure time of 3 seconds.

      Predicted band size : 87 kDa.


    ab114045 has not yet been referenced specifically in any publications.

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