Anti-ATF-4 antibody (ab85049)
Key features and details
- Rabbit polyclonal to ATF-4
- Suitable for: WB, ChIP
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ATF-4 antibody
See all ATF-4 primary antibodies -
Description
Rabbit polyclonal to ATF-4 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ChIPmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptide corresponding to Human ATF-4 (C terminal).
Database link: P18848 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide -
Concentration information loading...
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Purity
Protein A/G purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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ChIP Related Products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab85049 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (3) |
1/200 - 1/1000. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa).
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ChIP | (1) |
Use at an assay dependent concentration.
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Notes |
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WB
1/200 - 1/1000. Detects a band of approximately 39 kDa (predicted molecular weight: 39 kDa). |
ChIP
Use at an assay dependent concentration. |
Target
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Function
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. -
Sequence similarities
Belongs to the bZIP family.
Contains 1 bZIP domain. -
Cellular localization
Cytoplasm. Cell membrane. Nucleus. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. - Information by UniProt
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Database links
- Entrez Gene: 468 Human
- Entrez Gene: 11911 Mouse
- Entrez Gene: 79255 Rat
- Omim: 604064 Human
- SwissProt: P18848 Human
- SwissProt: Q06507 Mouse
- SwissProt: Q9ES19 Rat
- Unigene: 496487 Human
see all -
Alternative names
- Activating transcription factor 4 antibody
- ATF 4 antibody
- ATF4 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (11)
ab85049 has been referenced in 11 publications.
- Deng X et al. ATF4-mediated histone deacetylase HDAC1 promotes the progression of acute pancreatitis. Cell Death Dis 12:5 (2021). PubMed: 33414424
- Ying Y et al. Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG. Aging (Albany NY) 13:8628-8642 (2021). PubMed: 33714955
- Al Madhoun A et al. Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells. Sci Rep 11:11893 (2021). PubMed: 34088951
- Di Marcantonio D et al. ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia. Mol Cell 81:2752-2764.e6 (2021). PubMed: 34081901
- Cagnetta R et al. Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring. Mol Cell 73:474-489.e5 (2019). PubMed: 30595434