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Anti-ATG16L1 antibody (ab64777)

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Overview

Product name

Anti-ATG16L1 antibody
See all ATG16L1 products (10) ...

Description

Rabbit polyclonal to ATG16L1

Tested applications

WB, IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Human

Immunogen

A synthetic peptide as a part of human and monkey ATG16L1 isoforms 1, 2, 3 conjugated to an immunogenic carrier protein.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS, Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Signal transduction >> Autophagy
Cardiovascular >> Heart >> Autophagy >> APG gene products
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ub-like Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab64777 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: 1/100 - 1/2000.Predi...Read more →

    WB: 1/100 - 1/2000.Predicted molecular weight: 68 kDa.(This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)

  • ShowHide

    IHC-P

     IHC-P: 1/100 - 1/2000.Pe...Read more →

    IHC-P: 1/100 - 1/2000.Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

  • IHC-Fr

     IHC-Fr: 1/100 - 1/2000.

    IHC-Fr: 1/100 - 1/2000.

Target

Function

Plays an essential role in autophagy.

Involvement in disease

Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10) [MIM:611081]. IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease.

Sequence similarities

Belongs to the WD repeat ATG16 family.
Contains 7 WD repeats.

Cellular localization

Cytoplasm. Preautophagosomal structure membrane. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5.

Target information above from: UniProt accessionQ676U5 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Form

There are 4 isoforms produced by alternative splicing.

Alternative names

  • FLJ00045 antibody
  • FLJ22677 antibody
  • A16L1_HUMAN antibody
  • APG16 like 1 antibody
  • APG16-like 1 antibody
  • APG16L antibody
  • APG16L beta antibody
  • ATG16 autophagy related 16 like 1 antibody
  • ATG16 autophagy related 16-like 1 (S. cerevisiae) antibody
  • ATG16 autophagy related 16-like 1 antibody
  • ATG16A antibody
  • ATG16L antibody
  • ATG16L1 antibody
  • Autophagy related protein 16 1 antibody
  • Autophagy-related protein 16-1 antibody
  • FLJ10035 antibody
  • FLJ10828 antibody
  • IBD10 antibody
  • OTTHUMP00000164391 antibody
  • OTTHUMP00000164393 antibody
  • OTTHUMP00000165876 antibody
  • OTTHUMP00000165877 antibody
  • WD repeat domain 30 antibody
  • WDR30 antibody
see all

Database links

References for Anti-ATG16L1 antibody (ab64777)

ab64777 has not yet been referenced specifically in any publications.

Publishing research using ab64777? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"