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Anti-ATP citrate lyase (phospho S455) antibody (ab59297)

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Overview

Product name

Anti-ATP citrate lyase (phospho S455) antibody
See all ATP citrate lyase products (6) ...

Description

Rabbit polyclonal to ATP citrate lyase (phospho S455)

Specificity

Detects endogenous levels of ATP Citrate Lyase only when phosphorylated at serine 455.

Tested applications

ELISA, IHC-Pmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic phosphopeptide derived from human ATP Citrate Lyase around the phosphorylation site of serine 455 (T-A-SP-F-S).

Positive control

Human colon carcinoma tissue

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Signal Transduction >> Metabolism >> Lipid metabolism
Signal Transduction >> Metabolism >> Energy Metabolism

  • Immunohistochemistry (Paraffin-embedded sections) - ATP citrate lyase (phospho S455) antibody (ab59297)Immunohistochemistry (Paraffin-embedded sections) - ATP citrate lyase (phospho S455) antibody (ab59297) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab59297 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ELISA

     ELISA: 1/5000

    ELISA: 1/5000

  • 1 Image

    IHC-P

     IHC-P: 1/50 - 1/100.

    IHC-P: 1/50 - 1/100.

Target

Function

ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Sequence similarities

In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.

Post-translational
modifications

ISGylated.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionP53396 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ACL antibody
  • Acly antibody
  • ACLY_HUMAN antibody
  • ATP citrate (pro-S) lyase antibody
  • ATP citrate synthase antibody
  • ATP-citrate (pro-S-)-lyase antibody
  • ATP-citrate synthase antibody
  • Citrate cleavage enzyme antibody
  • EC 2.3.3.8 antibody
see all

Database links

see all

Anti-ATP citrate lyase (phospho S455) antibody images:

  Immunohistochemistry (Paraffin-embedded sections) - ATP citrate lyase (phospho S455) antibody (ab59297)

Immunohistochemistry (Paraffin-embedded sections) - ATP citrate lyase (phospho S455) antibody (ab59297)

Ab59297 at 1/50 dilution staining human colon carcinoma without (left) and with (right) immunizing peptide; paraffin embedded.

References for Anti-ATP citrate lyase (phospho S455) antibody (ab59297)

ab59297 has not yet been referenced specifically in any publications.

Publishing research using ab59297? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"