Anti-ATP2C1 antibody (ab126171)
Key features and details
- Rabbit polyclonal to ATP2C1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ATP2C1 antibody
See all ATP2C1 primary antibodies -
Description
Rabbit polyclonal to ATP2C1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow -
Immunogen
Recombinant fragment, corresponding to a region within internal sequence amino acids 483-721 of Human ATP2C1 (UniProt P98194).
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Positive control
- HeLa whole cell lysate; A549 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab126171 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 101 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 101 kDa. |
Target
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Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. -
Tissue specificity
Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney. -
Involvement in disease
Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD) [MIM:169600]; also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. -
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. -
Cellular localization
Golgi apparatus membrane. - Information by UniProt
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Database links
- Entrez Gene: 27032 Human
- Entrez Gene: 235574 Mouse
- Entrez Gene: 170699 Rat
- Omim: 604384 Human
- SwissProt: P98194 Human
- SwissProt: Q80XR2 Mouse
- SwissProt: Q64566 Rat
- Unigene: 584884 Human
see all -
Alternative names
- 1700121J11Rik antibody
- AT2C1_HUMAN antibody
- ATP dependent Ca(2+) pump PMR1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab126171 has been referenced in 2 publications.
- He J et al. OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway. Oxid Med Cell Longev 2021:4805040 (2021). PubMed: 34815829
- He J et al. Olfactory Mucosa Mesenchymal Stem Cells Alleviate Cerebral Ischemia/Reperfusion Injury Via Golgi Apparatus Secretory Pathway Ca2+ -ATPase Isoform1. Front Cell Dev Biol 8:586541 (2020). PubMed: 33195239