Overview

  • Product name
  • Description
    Mouse polyclonal to ATP2C1
  • Host species
    Mouse
  • Tested applications
    Suitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-919 of Human ATP2C1 (NP_055197.2).

  • Positive control
    • ATP2C1 transfected 293T cell lysate; HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab167509 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 101 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • Function
    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
  • Tissue specificity
    Found in most tissues except colon, thymus, spleen and leukocytes. Most abundant in keratinocytes and kidney.
  • Involvement in disease
    Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD) [MIM:169600]; also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD.
  • Sequence similarities
    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
  • Cellular localization
    Golgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1700121J11Rik antibody
    • AT2C1_HUMAN antibody
    • ATP dependent Ca(2+) pump PMR1 antibody
    • ATP-dependent Ca(2+) pump PMR1 antibody
    • ATP2C1 antibody
    • ATP2C1A antibody
    • ATPase 2C1 antibody
    • ATPase Ca(2+) sequestering antibody
    • ATPase Ca++ transporting type 2C member 1 antibody
    • AW061228 antibody
    • BCPM antibody
    • Calcium transporting ATPase type 2C member 1 antibody
    • Calcium-transporting ATPase type 2C member 1 antibody
    • D930003G21Rik antibody
    • HHD antibody
    • hSPCA1 antibody
    • HUSSY 28 antibody
    • KIAA1347 antibody
    • MGC58010 antibody
    • MGC93231 antibody
    • OTTHUMP00000216066 antibody
    • OTTHUMP00000216068 antibody
    • OTTHUMP00000216069 antibody
    • OTTHUMP00000216071 antibody
    • OTTHUMP00000216072 antibody
    • OTTHUMP00000216073 antibody
    • OTTHUMP00000216074 antibody
    • OTTHUMP00000216075 antibody
    • PMR1 antibody
    • PMR1, rat, homolog of antibody
    • PMR1L antibody
    • Secretory pathway Ca(2+) ATPase 1 antibody
    • Secretory pathway Ca(2+)-transporting ATPase antibody
    • Secretory pathway Ca2+/Mn2+ ATPase 1 antibody
    • SPCA antibody
    • SPCA1 antibody
    see all

Images

  • All lanes : Anti-ATP2C1 antibody (ab167509) at 1 µg/ml

    Lane 1 : ATP2C1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat anti-Mouse IgG HRP at 1/2500 dilution

    Predicted band size: 101 kDa

  • Immunofluorescent analysis of HeLa cells labeling ATP2C1 with ab167509 at 10 µg/ml.

References

ab167509 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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