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Storage instructions Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg +2 and Ca +2), 150mM Sodium chloride, pH 7.4
Concentration information loading...
Purity Immunogen affinity purified
Purification notes Affinity purified from rabbit antiserum by affinity chromatography, using epitope specific immunogen.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
1/1000. Detects a band of approximately 85 kDa (predicted molecular weight: 85 kDa).
Function Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Tissue specificity Ubiquitous.
Sequence similarities Belongs to the ATRIP family.
Domain The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
Post-translational modifications Phosphorylated by ATR.
Cellular localization Nucleus. Redistributes to discrete nuclear foci upon DNA damage.
Information by UniProt
ATM and Rad3 related interacting protein antibody
Anti-ATRIP antibody images
Immunohistochemistry (Paraffin-embedded sections) - ATRIP antibody (ab59346)
ab59346, at a 1/50 dilution, staining human ATRIP in lung carcinoma, using Immunohistochemistry, Paraffin embedded tissue, in the absence (left image) and presence of the immunizing peptide (right image).
Western blot - Anti-ATRIP antibody (ab59346)
Anti-ATRIP antibody (ab59346) at 1/1000 dilution + Human mammary cell lysate at 50000 cells Secondary Goat anti-rabbit HRP IgG at 1/2500 dilution Developed using the ECL technique Performed under reducing conditions. Predicted band size : 85 kDa Observed band size : 85 kDa Exposure time : 1 minute This image is courtesy of an anonymous Abreview
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