Overview

  • Product nameAnti-ATTY antibody
    See all ATTY primary antibodies
  • Description
    Rabbit polyclonal to ATTY
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 285-315 of Human ATTY (NP_000344).

  • Positive control
    • K562 cell line lysates. Human hepatocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab103992 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionTransaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has no transaminase activity towards phenylalanine.
  • PathwayAmino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.
  • Involvement in diseaseDefects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.
  • Sequence similaritiesBelongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • ATTY_HUMAN antibody
    • L-tyrosine:2-oxoglutarate aminotransferase antibody
    • TAT antibody
    • Tyrosine aminotransferase antibody
    • Tyrosine aminotransferase, cytosolic antibody
    see all

Anti-ATTY antibody images

  • Anti-ATTY antibody (ab103992) at 1/100 dilution + K562 cell line lysates at 35 µg

    Predicted band size : 50 kDa
  • ab103992 at 1/50 dilution staining ATTY by immunohistochemistry in formalin fixed and paraffin embedded Human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining

References for Anti-ATTY antibody (ab103992)

ab103992 has not yet been referenced specifically in any publications.

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