Overview

  • Product name
  • Description
    Rabbit polyclonal to ATXN10
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Guinea pig, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residues 1 and 50 of human ATXN10 (NP_037368.1)

  • Positive control
    • HeLa whole cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: 8mM PBS, 60mM Citrate, 150mM Tris, pH 7-8
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab72101 was affinity purified using an epitope specific to ATXN10 immobilized on solid support.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab72101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
    • Tissue specificity
      Expressed in the central nervous system.
    • Involvement in disease
      Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10) [MIM:603516]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).
    • Sequence similarities
      Belongs to the ataxin-10 family.
    • Cellular localization
      Cytoplasm > perinuclear region.
    • Information by UniProt
    • Database links
    • Alternative names
      • Ataxin 10 antibody
      • Ataxin-10 antibody
      • ATX10_HUMAN antibody
      • Atxn10 antibody
      • Brain protein E46 homolog antibody
      • E46L antibody
      • FLJ37990 antibody
      • HUMEEP antibody
      • Like mouse brain protein E46 antibody
      • OTTHUMP00000197383 antibody
      • SCA10 antibody
      • Spinocerebellar ataxia 10 antibody
      • Spinocerebellar ataxia type 10 protein antibody
      see all

    Images

    • Detection of ATXN10 by Western Blot of Immunprecipitate.
      anti-ATXN10 at 1µg/ml staining ATXN10 in HeLa whole cell lysate immunoprecipitated using ab72101 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 10 seconds.

    References

    ab72101 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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