Overview

  • Product name
  • Description
    Rabbit polyclonal to ATXN7L3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Zebrafish
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-174 of Human ATXN7L3 (Uniprot ID: Q14CW9).

  • Positive control
    • Jurkat, Raji, K562, THP1 and HL60 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab154762 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 39 kDa.

Target

  • Function
    Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.
  • Sequence similarities
    Belongs to the SGF11 family.
    Contains 1 SCA7 domain.
    Contains 1 SGF11-type zinc finger.
  • Domain
    The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.
    The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AT7L3_HUMAN antibody
    • Ataxin 7 like 3 antibody
    • Ataxin 7 like protein 3 antibody
    • Ataxin-7-like protein 3 antibody
    • atxn7l3 antibody
    • SAGA associated factor 11 homolog antibody
    • SAGA-associated factor 11 homolog antibody
    see all

Images

  • All lanes : Anti-ATXN7L3 antibody (ab154762) at 1/1000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : Raji whole cell lysate
    Lane 3 : K562 whole cell lysate
    Lane 4 : THP1 whole cell lysate
    Lane 5 : HL60 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 39 kDa



    10% SDS PAGE

References

ab154762 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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