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ab2254 has been referenced in 104 publications.

  • Nixon BR  et al. Alterations in sarcomere function modify the hyperplastic to hypertrophic transition phase of mammalian cardiomyocyte development. JCI Insight 2:e90656 (2017). PubMed: 28239655
  • Liu B  et al. Cardiac resident macrophages are involved in hypoxia-induced postnatal cardiomyocyte proliferation. Mol Med Rep 15:3541-3548 (2017). PubMed: 28393210
  • Chopra A  et al. Efficient Activation of Apoptotic Signaling during Mitotic Arrest with AK301. PLoS One 11:e0153818 (2016). IF . PubMed: 27097159
  • Krupina K  et al. Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules. Dev Cell 36:63-78 (2016). PubMed: 26766443
  • Kamranvar SA  et al. Integrin signaling via FAK-Src controls cytokinetic abscission by decelerating PLK1 degradation and subsequent recruitment of CEP55 at the midbody. Oncotarget 7:30820-30 (2016). PubMed: 27127172
  • Petsalaki E & Zachos G Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. Nat Commun 7:11451 (2016). IF . PubMed: 27126587
  • Wolf B  et al. Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma. Cancer Res 76:5550-61 (2016). PubMed: 27488521
  • Capalbo L  et al. Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis. Open Biol 6:N/A (2016). Human . PubMed: 27784789
  • Phillips NE  et al. Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation. Elife 5:N/A (2016). IF . PubMed: 27700985
  • Yabuta N  et al. Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis. Heliyon 2:e00131 (2016). Human . PubMed: 27512725
  • Suzuki A  et al. Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells. Nat Commun 7:11056 (2016). PubMed: 27025988
  • McKenzie C  et al. Cross-regulation between Aurora B and Citron kinase controls midbody architecture in cytokinesis. Open Biol 6:N/A (2016). PubMed: 27009191
  • Lanza C  et al. Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects. Cell Cycle 15:1363-75 (2016). PubMed: 27070276
  • Damiani D  et al. Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors. Nat Commun 7:13509 (2016). IHC . PubMed: 27848932
  • de Souza EE  et al. Human Nek7-interactor RGS2 is required for mitotic spindle organization. Cell Cycle 14:656-67 (2015). PubMed: 25664600
  • González-Loyola A  et al. Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development. Mol Cell Biol 35:3566-78 (2015). PubMed: 26240282
  • Sadaie M  et al. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell 26:2971-85 (2015). WB ; Human . PubMed: 26133385
  • Platani M  et al. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes. J Cell Biol 210:45-62 (2015). ICC/IF ; Human . PubMed: 26124292
  • Jiang J  et al. Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis. Proc Natl Acad Sci U S A 112:9046-51 (2015). IHC-P ; Mouse . PubMed: 26153423
  • Hatzistergos KE  et al. S-Nitrosoglutathione Reductase Deficiency Enhances the Proliferative Expansion of Adult Heart Progenitors and Myocytes Post Myocardial Infarction. J Am Heart Assoc 4:N/A (2015). IHC-P ; Mouse . PubMed: 26178404
  • Kobayashi A  et al. Therapeutic potential of mitotic interaction between the nucleoporin Tpr and aurora kinase A. Cell Cycle 14:1447-58 (2015). PubMed: 25789545
  • Huna A  et al. Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle 14:2969-84 (2015). PubMed: 26102294
  • Papini D  et al. TD-60 links RalA GTPase function to the CPC in mitosis. Nat Commun 6:7678 (2015). PubMed: 26158537
  • Park H  et al. Ewing sarcoma EWS protein regulates midzone formation by recruiting Aurora B kinase to the midzone. Cell Cycle 13:2391-9 (2014). PubMed: 25483190
  • Wang T  et al. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation. J Cell Sci 127:2483-92 (2014). Mouse . PubMed: 24706948
  • Gohard FH  et al. Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo. Open Biol 4:140163 (2014). ICC/IF . PubMed: 25392451
  • Balboula AZ & Schindler K Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet 10:e1004194 (2014). ICC/IF ; Mouse . PubMed: 24586209
  • Banerjee B  et al. EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol 204:947-63 (2014). Human . PubMed: 24616220
  • Petsalaki E & Zachos G Chk2 prevents mitotic exit when the majority of kinetochores are unattached. J Cell Biol 205:339-56 (2014). PubMed: 24798733
  • Mahadevan D  et al. Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2. PLoS One 9:e95184 (2014). Human . PubMed: 24893165
  • Shrestha RL  et al. TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes. Open Biol 4:130108 (2014). ICC/IF ; Human . PubMed: 24898139
  • Vassilopoulos A  et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene 0:N/A (2014). PubMed: 25088202
  • d'Alcontres MS  et al. TopoIIa prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres. Cell Cycle 13:1463-81 (2014). PubMed: 24626180
  • Li Y  et al. Acute myocardial infarction induced functional cardiomyocytes to re-enter the cell cycle. Am J Transl Res 5:327-35 (2013). PubMed: 23634243
  • Yu Y & Munger K Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis. Virology 446:251-9 (2013). PubMed: 24074588
  • Murray MJ  et al. LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res 73:4872-84 (2013). PubMed: 23774216
  • Petsalaki E & Zachos G Chk1 and Mps1 jointly regulate correction of merotelic kinetochore attachments. J Cell Sci 126:1235-46 (2013). PubMed: 23321637
  • Soeda S  et al. v-Src causes delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone during cytokinesis failure. Exp Cell Res 319:1382-97 (2013). PubMed: 23562843
  • Trakala M  et al. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1). Cell Cycle 12:1030-41 (2013). WB, ICC/IF ; Mouse . PubMed: 23428904
  • Pe'er T  et al. Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex. PLoS One 8:e57532 (2013). ICC/IF ; Human . PubMed: 23469016
  • Salmela AL  et al. Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases. Carcinogenesis 34:436-45 (2013). PubMed: 23104179
  • Ladage D  et al. Stimulating myocardial regeneration with periostin Peptide in large mammals improves function post-myocardial infarction but increases myocardial fibrosis. PLoS One 8:e59656 (2013). IHC-Fr ; Pig . PubMed: 23700403
  • Hofmann JC  et al. The prp19 complex directly functions in mitotic spindle assembly. PLoS One 8:e74851 (2013). PubMed: 24069358
  • Heallen T  et al. Hippo signaling impedes adult heart regeneration. Development 140:4683-90 (2013). Human . PubMed: 24255096
  • Blakemore LM  et al. Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage. Carcinogenesis 34:351-60 (2013). IF . PubMed: 23125222
  • Jackson TR  et al. DNA damage causes TP53-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells. Cell Cycle 12:430-41 (2013). PubMed: 23287532
  • Qi W  et al. Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment. Leuk Res 37:434-9 (2013). PubMed: 23153524
  • Gully CP  et al. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A 109:E1513-22 (2012). PubMed: 22611192
  • Wolter P  et al. GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stability. J Cell Sci 125:2393-406 (2012). PubMed: 22344256
  • Shan W  et al. A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma. Clin Cancer Res 18:3352-65 (2012). WB . PubMed: 22535157
  • Cho HS  et al. Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun 3:1072 (2012). PubMed: 22990868
  • von Gise A  et al. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 109:2394-9 (2012). IHC-P ; Mouse . PubMed: 22308401
  • Mahadevan D  et al. Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma. Clin Cancer Res 18:2210-9 (2012). PubMed: 22374334
  • Kuratnik A  et al. Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. Biochem Pharmacol 83:1217-28 (2012). PubMed: 22306067
  • Lin Y  et al. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer 107:1692-701 (2012). WB . PubMed: 23037716
  • De Antoni A  et al. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol 199:269-84 (2012). IF . PubMed: 23071153
  • Qi W  et al. Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma. Biochem Pharmacol 81:881-90 (2011). PubMed: 21291867
  • Lee M  et al. A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. Oncogene 30:3360-9 (2011). IF . PubMed: 21399666
  • Blanchard Z  et al. Geminin overexpression induces mammary tumors via suppressing cytokinesis. Oncotarget 2:1011-27 (2011). PubMed: 22184288
  • Tardáguila M  et al. Aurora kinase B activity is modulated by thyroid hormone during transcriptional activation of pituitary genes. Mol Endocrinol 25:385-93 (2011). WB . PubMed: 21239609
  • Fernández-Miranda G  et al. Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development 138:2661-72 (2011). PubMed: 21613325
  • Cheung CH  et al. BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells. PLoS One 6:e23485 (2011). WB ; Human . PubMed: 21887256
  • Bernal JA & Venkitaraman AR A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission. J Cell Biol 192:969-78 (2011). PubMed: 21422227
  • Santo L  et al. Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clin Cancer Res 17:3259-71 (2011). IHC . PubMed: 21430070
  • Huna A  et al. Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells. J Aging Res 2011:103253 (2011). PubMed: 21629737
  • Petsalaki E  et al. Phosphorylation at serine 331 is required for Aurora B activation. J Cell Biol 195:449-66 (2011). PubMed: 22024163
  • Trimborn M  et al. Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function. PLoS One 5:e9242 (2010). PubMed: 20169082
  • Davoli T  et al. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 141:81-93 (2010). PubMed: 20371347
  • Becker M  et al. Centromere localization of INCENP-aurora B is sufficient to support spindle checkpoint function. Cell Cycle 9: (2010). WB ; Human . PubMed: 20372054
  • Fietz SA  et al. OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling. Nat Neurosci 13:690-9 (2010). IHC-Fr ; Human . PubMed: 20436478
  • Colnaghi R & Wheatley SP Liaisons between Survivin and Plk1 during Cell Division and Cell Death. J Biol Chem 285:22592-604 (2010). WB, ICC/IF ; Human . PubMed: 20427271
  • Santaguida S  et al. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol 190:73-87 (2010). WB, ICC/IF ; Human . PubMed: 20624901
  • Morozova O  et al. System-Level Analysis of Neuroblastoma Tumor-Initiating Cells Implicates AURKB as a Novel Drug Target for Neuroblastoma. Clin Cancer Res 16:4572-4582 (2010). WB ; Human . PubMed: 20651058
  • Mackay DR  et al. Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J Cell Biol 191:923-31 (2010). ICC/IF ; Human . PubMed: 21098116
  • Bethel CR  et al. Gene expression changes are age-dependent and lobe-specific in the brown Norway rat model of prostatic hyperplasia. Prostate 69:838-50 (2009). PubMed: 19204916
  • Ferri F  et al. Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase. Nucleic Acids Res 37:5071-80 (2009). WB, IP ; Mouse . PubMed: 19542185
  • Drews-Elger K  et al. The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS One 4:e5245 (2009). PubMed: 19381288
  • Salmela AL  et al. Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint. Carcinogenesis 30:1032-40 (2009). PubMed: 19395653
  • Platani M  et al. The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell 20:5260-75 (2009). ICC/IF ; Human . PubMed: 19864462
  • Lorts A  et al. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circ Res 104:e1-7 (2009). ICC/IF ; Mouse . PubMed: 19038863
  • Aihara A  et al. The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma. J Hepatol : (2009). WB ; Human . PubMed: 19913935
  • Yasen M  et al. Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue. Cancer Sci 100:472-80 (2009). WB ; Human . PubMed: 19134008
  • Hans F  et al. Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B. Mol Biol Cell 20:3491-502 (2009). PubMed: 19494039
  • Erenpreisa J  et al. Endopolyploidy in irradiated p53-deficient tumour cell lines: persistence of cell division activity in giant cells expressing Aurora-B kinase. Cell Biol Int 32:1044-56 (2008). ICC/IF ; Human . PubMed: 18602486
  • Logarinho E  et al. The Human Spindle Assembly Checkpoint Protein Bub3 Is Required for the Establishment of Efficient Kinetochore-Microtubule Attachments. Mol Biol Cell : (2008). ICC/IF ; Human . PubMed: 18199686
  • Yamauchi T  et al. A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J 27:1852-62 (2008). ICC/IF ; Human . PubMed: 18548008
  • Ebelt H  et al. E2F2 expression induces proliferation of terminally differentiated cardiomyocytes in vivo. Cardiovasc Res : (2008). PubMed: 18628254
  • Zajac M  et al. Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines. Mol Cancer Ther 7:2358-66 (2008). WB ; Human . PubMed: 18723483
  • Ebelt H  et al. Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. J Mol Cell Cardiol 45:411-9 (2008). PubMed: 18634800
  • Amabile G  et al. The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts. Cell Death Differ : (2008). WB . PubMed: 18974773
  • Li M  et al. c-kit is required for cardiomyocyte terminal differentiation. Circ Res 102:677-85 (2008). IHC-P ; Mouse . PubMed: 18258857
  • North BJ & Verdin E Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2:e784 (2007). ICC/IF . PubMed: 17726514
  • Wheatley SP  et al. Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle 6:1220-30 (2007). PubMed: 17457057
  • Hontz AE  et al. Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. Cancer Res 67:2957-63 (2007). PubMed: 17409401
  • Sabbattini P  et al. A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. EMBO J 26:4657-69 (2007). WB, ICC/IF ; Mouse . PubMed: 17948062
  • Skoufias DA  et al. Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed. J Cell Biol 179:671-85 (2007). ICC/IF ; Human . PubMed: 18025303
  • Di Fiore B & Pines J Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C. J Cell Biol 177:425-37 (2007). ICC/IF ; Human . PubMed: 17485488
  • Thullberg M  et al. Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts. Proc Natl Acad Sci U S A 104:20338-43 (2007). PubMed: 18077377
  • Kulkarni AA  et al. DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma. Clin Cancer Res 13:6153-61 (2007). PubMed: 17947481
  • Koller E  et al. Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development. Cancer Res 66:2059-66 (2006). PubMed: 16489005
  • Li Y  et al. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev 20:2566-79 (2006). PubMed: 16980585
  • Song J  et al. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 22:621-31 (2005). PubMed: 15894279
  • Kapoor P  et al. EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. Mol Cell Biol 25:4934-45 (2005). PubMed: 15923612
  • Gassmann R  et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol 166:179-91 (2004). PubMed: 15249581

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