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ab2254 has been referenced in 59 publications.

  • Petsalaki E & Zachos G Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint. Nat Commun 7:11451 (2016). IF . PubMed: 27126587
  • Platani M  et al. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes. J Cell Biol 210:45-62 (2015). ICC/IF ; Human . PubMed: 26124292
  • Jiang J  et al. Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis. Proc Natl Acad Sci U S A 112:9046-51 (2015). IHC-P ; Mouse . PubMed: 26153423
  • Hatzistergos KE  et al. S-Nitrosoglutathione Reductase Deficiency Enhances the Proliferative Expansion of Adult Heart Progenitors and Myocytes Post Myocardial Infarction. J Am Heart Assoc 4:N/A (2015). IHC-P ; Mouse . PubMed: 26178404
  • Wang T  et al. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation. J Cell Sci 127:2483-92 (2014). Mouse . PubMed: 24706948
  • Gohard FH  et al. Targeting the INCENP IN-box-Aurora B interaction to inhibit CPC activity in vivo. Open Biol 4:140163 (2014). ICC/IF . PubMed: 25392451
  • Balboula AZ & Schindler K Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet 10:e1004194 (2014). ICC/IF ; Mouse . PubMed: 24586209
  • Banerjee B  et al. EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B. J Cell Biol 204:947-63 (2014). Human . PubMed: 24616220
  • Petsalaki E & Zachos G Chk2 prevents mitotic exit when the majority of kinetochores are unattached. J Cell Biol 205:339-56 (2014). PubMed: 24798733
  • Mahadevan D  et al. Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2. PLoS One 9:e95184 (2014). Human . PubMed: 24893165
  • Shrestha RL  et al. TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes. Open Biol 4:130108 (2014). ICC/IF ; Human . PubMed: 24898139
  • Vassilopoulos A  et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene 0:N/A (2014). PubMed: 25088202
  • Trakala M  et al. Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1). Cell Cycle 12:1030-41 (2013). WB, ICC/IF ; Mouse . PubMed: 23428904
  • Pe'er T  et al. Gas2l3, a novel constriction site-associated protein whose regulation is mediated by the APC/C Cdh1 complex. PLoS One 8:e57532 (2013). ICC/IF ; Human . PubMed: 23469016
  • Salmela AL  et al. Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases. Carcinogenesis 34:436-45 (2013). PubMed: 23104179
  • Ladage D  et al. Stimulating myocardial regeneration with periostin Peptide in large mammals improves function post-myocardial infarction but increases myocardial fibrosis. PLoS One 8:e59656 (2013). IHC-Fr ; Pig . PubMed: 23700403
  • Hofmann JC  et al. The prp19 complex directly functions in mitotic spindle assembly. PLoS One 8:e74851 (2013). PubMed: 24069358
  • Heallen T  et al. Hippo signaling impedes adult heart regeneration. Development 140:4683-90 (2013). Human . PubMed: 24255096
  • von Gise A  et al. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 109:2394-9 (2012). IHC-P ; Mouse . PubMed: 22308401
  • Mahadevan D  et al. Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma. Clin Cancer Res 18:2210-9 (2012). PubMed: 22374334
  • Kuratnik A  et al. Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest. Biochem Pharmacol 83:1217-28 (2012). PubMed: 22306067
  • Tardáguila M  et al. Aurora kinase B activity is modulated by thyroid hormone during transcriptional activation of pituitary genes. Mol Endocrinol 25:385-93 (2011). WB . PubMed: 21239609
  • Fernández-Miranda G  et al. Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development 138:2661-72 (2011). PubMed: 21613325
  • Cheung CH  et al. BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells. PLoS One 6:e23485 (2011). WB ; Human . PubMed: 21887256
  • Trimborn M  et al. Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function. PLoS One 5:e9242 (2010). PubMed: 20169082
  • Davoli T  et al. Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 141:81-93 (2010). PubMed: 20371347
  • Becker M  et al. Centromere localization of INCENP-aurora B is sufficient to support spindle checkpoint function. Cell Cycle 9: (2010). WB ; Human . PubMed: 20372054
  • Fietz SA  et al. OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling. Nat Neurosci 13:690-9 (2010). IHC-Fr ; Human . PubMed: 20436478
  • Colnaghi R & Wheatley SP Liaisons between Survivin and Plk1 during Cell Division and Cell Death. J Biol Chem 285:22592-604 (2010). WB, ICC/IF ; Human . PubMed: 20427271
  • Santaguida S  et al. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol 190:73-87 (2010). WB, ICC/IF ; Human . PubMed: 20624901
  • Morozova O  et al. System-Level Analysis of Neuroblastoma Tumor-Initiating Cells Implicates AURKB as a Novel Drug Target for Neuroblastoma. Clin Cancer Res 16:4572-4582 (2010). WB ; Human . PubMed: 20651058
  • Mackay DR  et al. Defects in nuclear pore assembly lead to activation of an Aurora B-mediated abscission checkpoint. J Cell Biol 191:923-31 (2010). ICC/IF ; Human . PubMed: 21098116
  • Ferri F  et al. Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase. Nucleic Acids Res 37:5071-80 (2009). WB, IP ; Mouse . PubMed: 19542185
  • Drews-Elger K  et al. The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress. PLoS One 4:e5245 (2009). PubMed: 19381288
  • Salmela AL  et al. Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint. Carcinogenesis 30:1032-40 (2009). PubMed: 19395653
  • Platani M  et al. The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell 20:5260-75 (2009). ICC/IF ; Human . PubMed: 19864462
  • Lorts A  et al. Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair. Circ Res 104:e1-7 (2009). ICC/IF ; Mouse . PubMed: 19038863
  • Aihara A  et al. The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma. J Hepatol : (2009). WB ; Human . PubMed: 19913935
  • Yasen M  et al. Expression of Aurora B and alternative variant forms in hepatocellular carcinoma and adjacent tissue. Cancer Sci 100:472-80 (2009). WB ; Human . PubMed: 19134008
  • Erenpreisa J  et al. Endopolyploidy in irradiated p53-deficient tumour cell lines: persistence of cell division activity in giant cells expressing Aurora-B kinase. Cell Biol Int 32:1044-56 (2008). ICC/IF ; Human . PubMed: 18602486
  • Logarinho E  et al. The Human Spindle Assembly Checkpoint Protein Bub3 Is Required for the Establishment of Efficient Kinetochore-Microtubule Attachments. Mol Biol Cell : (2008). ICC/IF ; Human . PubMed: 18199686
  • Yamauchi T  et al. A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J 27:1852-62 (2008). ICC/IF ; Human . PubMed: 18548008
  • Ebelt H  et al. E2F2 expression induces proliferation of terminally differentiated cardiomyocytes in vivo. Cardiovasc Res : (2008). PubMed: 18628254
  • Zajac M  et al. Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines. Mol Cancer Ther 7:2358-66 (2008). WB ; Human . PubMed: 18723483
  • Ebelt H  et al. Directed expression of dominant-negative p73 enables proliferation of cardiomyocytes in mice. J Mol Cell Cardiol 45:411-9 (2008). PubMed: 18634800
  • Amabile G  et al. The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts. Cell Death Differ : (2008). WB . PubMed: 18974773
  • North BJ & Verdin E Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2:e784 (2007). ICC/IF . PubMed: 17726514
  • Wheatley SP  et al. Phosphorylation by aurora-B negatively regulates survivin function during mitosis. Cell Cycle 6:1220-30 (2007). PubMed: 17457057
  • Hontz AE  et al. Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. Cancer Res 67:2957-63 (2007). PubMed: 17409401
  • Sabbattini P  et al. A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. EMBO J 26:4657-69 (2007). WB, ICC/IF ; Mouse . PubMed: 17948062
  • Skoufias DA  et al. Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed. J Cell Biol 179:671-85 (2007). ICC/IF ; Human . PubMed: 18025303
  • Di Fiore B & Pines J Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C. J Cell Biol 177:425-37 (2007). ICC/IF ; Human . PubMed: 17485488
  • Thullberg M  et al. Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts. Proc Natl Acad Sci U S A 104:20338-43 (2007). PubMed: 18077377
  • Kulkarni AA  et al. DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma. Clin Cancer Res 13:6153-61 (2007). PubMed: 17947481
  • Koller E  et al. Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development. Cancer Res 66:2059-66 (2006). PubMed: 16489005
  • Li Y  et al. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes Dev 20:2566-79 (2006). PubMed: 16980585
  • Song J  et al. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 22:621-31 (2005). PubMed: 15894279
  • Kapoor P  et al. EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases. Mol Cell Biol 25:4934-45 (2005). PubMed: 15923612
  • Gassmann R  et al. Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol 166:179-91 (2004). PubMed: 15249581

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