Avian Influenza A Neuraminidase peptide (ab39807)

Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Blocking - Blocking peptide for Anti-Avian Influenza A Neuraminidase antibody (ab21305)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • NA
    • Neuraminidase
  • Relevance
    Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
  • Cellular localization
    Cell Membrane; Virion membrane. Apical cell membrane; Single-pass type II membrane protein (By similarity).

References for Avian Influenza A Neuraminidase peptide (ab39807)

This product has been referenced in:
  • Cohen JE  et al. An innovative biologic system for photon-powered myocardium in the ischemic heart. Sci Adv 3:e1603078 (2017). IHC ; Rat . Read more (PubMed: 28630913) »

See 1 Publication for this product

Product Wall

Thank you very much for your interest in our proteins. Unfortunately we do currently only have synthetic Neuraminidase peptides in our catalogue and no functional Neuraminidase protein. The peptides are the ab39804 and the ab39807. We are adding consta...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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