Anti-Avian Influenza A Nucleoprotein antibody (ab119975)

Overview

  • Product nameAnti-Avian Influenza A Nucleoprotein antibody
  • Description
    Rabbit polyclonal to Avian Influenza A Nucleoprotein
  • Specificityab119975 crossreacts with Avian Influenza A Nucleoprotein in Avian and Chicken.
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Chicken
  • Immunogen

    Avian Influenza A Nucleoprotein (H5N1).

Properties

Applications

Our Abpromise guarantee covers the use of ab119975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • RelevanceEncapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
  • Cellular localizationVirion. Host nucleus.
  • Alternative names
    • Avian Influenza A NP antibody
    • NP antibody
    • Nucleocapsid protein antibody
    • Nucleoprotein antibody

References for Anti-Avian Influenza A Nucleoprotein antibody (ab119975)

ab119975 has not yet been referenced specifically in any publications.

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