Overview

  • Product name
    AY 9944 dihydrochloride
  • Description
    Hedgehog signaling inhibitor. Potent Δ7-dehydrocholesterol reductase inhibitor.
  • Biological description
    Hedgehog signaling inhibitor. Potent Δ7-dehydrocholesterol reductase inhibitor (IC50 = 13 nM). Inhibits cholesterol esterification and biosynthesis, and shows teratogenic effects in vivo. Orally active.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Jung S  et al. Social deficits in the AY-9944 mouse model of atypical absence epilepsy. Behav Brain Res 236:23-9 (2013). Read more (PubMed: 22944514) »
  • Stewart LS  et al. Environmental enrichment improves behavioral outcome in the AY-9944 model of childhood atypical absence epilepsy. Int J Neurosci 122:449-57 (2012). Read more (PubMed: 22471338) »
  • Botham KM & Boyd GS The effect of the hypocholesteremic drug, AY 9944 on the synthesis of bile salts in rat liver. Eur J Biochem 118:501-5 (1981). Read more (PubMed: 6170514) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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